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Biotechnology (Drug Discovery)


Biotechnology (Drug Discovery)



von: K.K. Bhutani, J.N. Govil

549,99 €

Verlag: Studium Press
Format: EPUB
Veröffentl.: 30.06.2014
ISBN/EAN: 9781626991590
Sprache: englisch
Anzahl Seiten: 590

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Beschreibungen

<span>Drug discovery and development is a long term process with involvement of multidisciplinary approach starting from lead identification to pathway analysis to late stage clinical development. A parallel processing of biological, chemical, pharmaceutical and clinical data can provide a solution to the drug discovery puzzle. This volume mainly concentrates on three main sections viz. discovery of lead molecules, updates on antimicrobials and current status of bio therapeutics development, and is hoped to be an essential reading for pharmacologists, medicinal chemists and pharmaceutical scientists working in academia and industry. The following topics have been covered in this volume: o Discovery of novel lead molecules from plant sources o New formulations and applications of natural genistein o Bacterial cell wall as reservoir of novel drug targets o General mechanism of bacterial virulence, role of quorum sensing in determining virulence and biofilm traits in bacteria o Antimicrobial characteristics of Burk holder produced metabolites o Microbes based therapy for the treatment of cancer o Development and production of natural and synthetic antimicrobial peptides o Regulatory processes for controlling the biosynthesis of Beta-lactic antibiotics in Penicillium chrysogenum and Acrimonies chrysogenum fungi o Review of stem cell research in human and veterinary therapeutics o Review on depression and its treatment by new antidepressant molecules o Diuretic effects of urea transporter inhibitors o BCL2 inhibitors for target specific cancer therapy o Trends in development of non-steroidal anti-inflammatory drugs o Review on biological effects of Eddy steroids and Bisacylhydrazene o Development of novel polygene antifungal formulations o Application of biotechnology in molecular pharmacognosy o Evaluation of toxic risk in drug therapy o Status of biotherapeutics development in India o Best practices followed in biopharmaceutical drug development The volume 7 contains 19 chapters from 51 researchers and/or academicians representing 6 nations, namely China, Egypt, India, Israel, Romania and Spain giving an overview of the various research activities being carried out in different parts of the world in the field of Drug Discovery. </span>
<span>Dr. K.K. Bhutani is the Director of National Institute of Pharmaceutical Education and Research (NIPER), Mohali, India. Dr. Bhutani obtained his Ph.D. in 1977 in Medicinal/Pharmaceutical Chemistry from Punjab University. He started his career in 1977 as Lecturer cum Senior Technical Officer from Institute of Pharmaceutical Sciences, Punjab University, Chandigarh. From 1978-1980, he worked as Manager (Research and Development) in an anti-tubercular drug manufacturing pharmaceutical company. Dr. Bhutani joined CSIR Regional Research Laboratory (Jammu) in 1980 and worked there till 1994 as Senior Scientist and Assistant Director, respectively. Since 1994, he is associated with NIPER and has held various key positions there. Dr. K. K. Bhutani has been project coordinator/principal investigator for more than two dozens major projects sponsored by national and international agencies, and big pharmaceutical industries. Dr. Bhutani has 127 research papers, 100 monographs, 19 patents, 14 review articles, and 8 books to his credit. Dr. Bhutani has been awarded visiting scientist fellowship to United States for the year 1991-92, and was profiled by Marquis “Who is who in the world” 1999 edition. He is also key member of several national and international expert groups on Medicinal Chemistry, Natural Products, Ayurvedic Pharmacopeia, Indian Pharmacopeia and Pharmaceuticals.</span>
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<span>Dr. J.N. Govil (B. 1945): Obtained his Masters and Doctorate degrees from Agra University, Agra, India. In his career span of 41 years research experience at the Indian Agricultural Research Institute, New Delhi, Dr.Govil has been involved in the breeding of cross-pollinated, often crosspollinated and self-pollinated crops. His research is mainly focussed on breeding for better quality, disease resistance, and for higher productivity in Pennisetum, Sorghum, maize, chickpea, and pigeonpea. Dr. Govil has been well exposed to the international scientific community through various training programmes. He took his training in "Plant exploration and collection techinques" through IBPGR in 1982. He was also awarded the prestigious FAO/IBPGR Fellowship in "Genetic resources, evaluation, and data preparation and management" at the University of Birmingham, UK.In 1983, he made visits to gene banks located in Europe. He also participated in various international seminars and conferences, including "Food and Legume Improvement for Asian Farming Systems" in Thailand in 1986. Dr. Govil is credited with more than ninety research papers in various journals of national and international repute in various aspects of genetics, crop breeding and topics on general agriculture. He has written and edited a number of books on medicinal Plants (2 Vols each of two Titles) and otherbooks with international authors. A new series "Recent Progress in Medicinal Plants" has been published by Studium Press, LLC, USA in 35 volumes under Dr. Govil's Chief Editorship. Dr. Govil has been Editor-in-Chief of the Journals, New Botanist (An International Journal of Plant Research)and Glimpses in Plant Research, since 1988. He has also guided more than a dozen post-graduate students. Dr. J.N. Govil was actively engaged through his leadership on pigeonpea breeding with special emphasis on "Breeding short duration pigeonpea varieties for improved management and low input conditions." Through his intensive efforts over the last 20 years, nine varieties of early pigeonpea in arhar-wheat rotation have been released at national level. Dr. Govil retired from ICAR service during the year 2007. Presently, he is working as Publishing Director and Managing Editor with Studium Press LLC, USA and has brought out nearly 300 academic publications during last five years. E-mail: jngovil@gmail.com;jngovil@hotmail.com </span>

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